Motor-free contractility of active biopolymer networks.

ABSTRACT

Contractility in animal cells is often generated by molecular motors such as myosin, which require polar substrates for their function. Motivated by recent experimental evidence of motor-independent contractility, we propose a robust motor-free mechanism that can generate contraction in biopolymer networks without the need for substrate polarity. We show that contractility is a natural consequence of active binding-unbinding of crosslinkers that breaks the principle of detailed balance, together with the asymmetric force-extension response of semiflexible biopolymers. We have extended our earlier work to discuss the motor-free contraction of viscoelastic biopolymer networks. We calculate the resulting contractile velocity using a microscopic model and show that it can be reduced to a simple coarse-grained model under certain limits. Our model may provide an explanation of recent reports of motor-independent contractility in cells. Our results also suggest a mechanism for generating contractile forces in synthetic active materials.