Pathology of hereditary renal cell carcinoma syndromes: Tuberous sclerosis complex (TSC).
Semin Diagn Pathol
; 41(1): 8-19, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-37993384
ABSTRACT
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease characterized by hamartomatous tumors involving multiple organs such as the brain, skin, heart, lung and kidney. TSC is caused by inactivating mutations in TSC1/TSC2, which encodes hamartin and tuberin, respectively, and forms a complex that regulates mechanistic target of rapamycin complex 1 (mTORC1), resulting in cell overgrowth and oncogenesis. Since a leading cause of morbidity and mortality in TSC relates to chronic kidney disease and the ability to preserve renal function, this review describes the important pathologic findings in TSC-associated renal neoplasms and their correlating sporadic counterparts. The most common renal tumor in TSC patients are AMLs, followed by a heterogeneous spectrum of renal epithelial tumors, which may provide clues to establishing a diagnosis of TSC.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Esclerosis Tuberosa
/
Carcinoma de Células Renales
/
Hamartoma
/
Neoplasias Renales
Límite:
Humans
Idioma:
En
Revista:
Semin Diagn Pathol
Asunto de la revista:
PATOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos