Surveillance of Complicated Mpox Cases Unresponsive to Oral Tecovirimat in Los Angeles County, 2022.
J Infect Dis
; 229(Supplement_2): S249-S254, 2024 Mar 26.
Article
en En
| MEDLINE
| ID: mdl-37995310
ABSTRACT
The Los Angeles County Department of Public Health established a surveillance system to identify complicated (advanced human immunodeficiency virus [HIV] or hospitalized) mpox cases. From 1 August to 30 November 2022, we identified 1581 mpox cases, of which 134 (8.5%) were complicated. A subset of 8 cases did not recover after either initiating or completing a course of oral tecovirimat. All 8 patients were HIV positive and had advanced HIV (CD4 count <200 cells/µL). We identified 8 distinct mutations previously associated with tecovirimat resistance in specimens collected from 6 patients. Ongoing surveillance of viral evolution requires close coordination between health departments and frontline providers.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Seropositividad para VIH
/
Mpox
Límite:
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Infect Dis
Año:
2024
Tipo del documento:
Article