ASO-mediated knockdown or kinase inhibition of <i>G2019S</i>-Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages.

Wallings, Rebecca L; Mark, Julian R; Staley, Hannah A; Gillett, Drew A; Neighbarger, Noelle; Kordasiewicz, Holly; Hirst, Warren D; Tansey, Malú Gámez

ASO-mediated knockdown or kinase inhibition of G2019S-Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages.

Wallings, Rebecca L; Mark, Julian R; Staley, Hannah A; Gillett, Drew A; Neighbarger, Noelle; Kordasiewicz, Holly; Hirst, Warren D; Tansey, Malú Gámez.

Afiliación

Wallings RL; Department of Neuroscience, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL 32610, USA.
Mark JR; Center for Translational Research in Neurodegenerative Disease, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL 32610, USA.
Staley HA; Department of Neuroscience, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL 32610, USA.
Gillett DA; Center for Translational Research in Neurodegenerative Disease, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL 32610, USA.
Neighbarger N; Department of Neuroscience, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL 32610, USA.
Kordasiewicz H; Center for Translational Research in Neurodegenerative Disease, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL 32610, USA.
Hirst WD; Department of Neuroscience, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL 32610, USA.
Tansey MG; Center for Translational Research in Neurodegenerative Disease, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL 32610, USA.

Mol Ther Nucleic Acids ; 34: 102064, 2023 Dec 12.

Article en En | MEDLINE | ID: mdl-38028198

Palabras clave

LRRK2; MT: Oligonucleotides: Therapies and Applications; antigen presentation; antisense oligonucleotide; immune response; lysosomal tubules

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Mol Ther Nucleic Acids Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos