Risk factors and outcomes of melanoma in children and adolescents: A retrospective multicenter study.
J Am Acad Dermatol
; 90(4): 716-726, 2024 Apr.
Article
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| MEDLINE
| ID: mdl-38040338
ABSTRACT
BACKGROUND:
Pediatric melanoma presents with distinct clinical features compared to adult disease.OBJECTIVE:
Characterize risk factors and negative outcomes in pediatric melanoma.METHODS:
Multicenter retrospective study of patients under 20 years diagnosed with melanoma between January 1, 1995 and June 30, 2015 from 11 academic medical centers.RESULTS:
Melanoma was diagnosed in 317 patients, 73% of whom were diagnosed in adolescence (age ≥11). Spitzoid (31%) and superficial spreading (26%) subtypes were most common and 11% of cases arose from congenital nevi. Sentinel lymph node biopsy was performed in 68% of cases and positive in 46%. Fatality was observed in 7% of cases. Adolescent patients with melanoma were more likely to have family history of melanoma (P = .046) compared to controls.LIMITATIONS:
Retrospective nature, cohort size, control selection, and potential referral bias.CONCLUSION:
Pediatric melanoma has diverse clinical presentations. Better understanding of these cases and outcomes may facilitate improved risk stratification of pediatric melanoma.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
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Melanoma
Límite:
Adolescent
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Adult
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Child
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Humans
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
2024
Tipo del documento:
Article