Cucurbitacin E reduces IL-1ß-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes.

Wang, Lin; Xu, Hui; Li, Xin; Chen, Hongwei; Zhang, Haigang; Zhu, Xunpeng; Lin, Zhijie; Guo, Shilei; Bao, Zhibo; Rui, Haicheng; He, Wei; Zhang, Hui

Wang, Lin; Xu, Hui; Li, Xin; Chen, Hongwei; Zhang, Haigang; Zhu, Xunpeng; Lin, Zhijie; Guo, Shilei; Bao, Zhibo; Rui, Haicheng; He, Wei; Zhang, Hui.

Afiliación

Wang L; Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Xu H; Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Li X; School of Basic Medicine Sciences, Anhui Medical University, Hefei, Anhui Province, China.
Chen H; Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Zhang H; Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Zhu X; Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Lin Z; Anhui Medical University, Hefei, Anhui Province, China.
Guo S; Anhui Medical University, Hefei, Anhui Province, China.
Bao Z; Anhui Medical University, Hefei, Anhui Province, China.
Rui H; Anhui Medical University, Hefei, Anhui Province, China.
He W; School of Basic Medicine Sciences, Anhui Medical University, Hefei, Anhui Province, China. weihe@ahmu.edu.cn.
Zhang H; Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China. zhanghui@ahmu.edu.cn.

J Transl Med ; 21(1): 880, 2023 12 04.

Article en En | MEDLINE | ID: mdl-38049841

Asunto(s)

Condrocitos; Osteoartritis de la Rodilla; Ratones; Animales; Humanos; Proteínas Proto-Oncogénicas c-akt/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Interleucina-1beta/metabolismo; Simulación del Acoplamiento Molecular; Ratones Endogámicos C57BL; Inflamación/patología; Meniscos Tibiales; Osteoartritis de la Rodilla/patología; FN-kappa B/metabolismo

Palabras clave

Cellular thermal shift assay; Cucurbitacin E; DMM; Molecular docking; Molecular dynamics simulation; Osteoarthritis; PI3K/Akt

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Condrocitos / Osteoartritis de la Rodilla Límite: Animals / Humans Idioma: En Revista: J Transl Med Año: 2023 Tipo del documento: Article País de afiliación: China

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