Contrast Sensitivity of ON and OFF Human Retinal Pathways in Myopia.
J Neurosci
; 44(3)2024 Jan 17.
Article
en En
| MEDLINE
| ID: mdl-38050109
ABSTRACT
The human visual cortex processes light and dark stimuli with ON and OFF pathways that are differently modulated by luminance contrast. We have previously demonstrated that ON cortical pathways have higher contrast sensitivity than OFF cortical pathways and the difference increases with luminance range (defined as the maximum minus minimum luminance in the scene). Here, we demonstrate that these ON-OFF cortical differences are already present in the human retina and that retinal responses measured with electroretinography are more affected by reductions in luminance range than cortical responses measured with electroencephalography. Moreover, we show that ON-OFF pathway differences measured with electroretinography become more pronounced in myopia, a visual disorder that elongates the eye and blurs vision at far distance. We find that, as the eye axial length increases across subjects, ON retinal pathways become less responsive, slower in response latency, less sensitive, and less effective and slower at driving pupil constriction. Based on these results, we conclude that myopia is associated with a deficit in ON pathway function that decreases the ability of the retina to process low contrast and regulate retinal illuminance in bright environments.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sensibilidad de Contraste
/
Miopía
Límite:
Humans
Idioma:
En
Revista:
J Neurosci
Año:
2024
Tipo del documento:
Article