TRAPs: the 'elevator-with-an-operator' mechanism.
Trends Biochem Sci
; 49(2): 134-144, 2024 02.
Article
en En
| MEDLINE
| ID: mdl-38102017
ABSTRACT
Tripartite ATP-independent periplasmic (TRAP) transporters are nutrient-uptake systems found in bacteria and archaea. These evolutionary divergent transporter systems couple a substrate-binding protein (SBP) to an elevator-type secondary transporter, which is a first-of-its-kind mechanism of transport. Here, we highlight breakthrough TRAP transporter structures and recent functional data that probe the mechanism of transport. Furthermore, we discuss recent structural and biophysical studies of the ion transporter superfamily (ITS) members and highlight mechanistic principles that are relevant for further exploration of the TRAP transporter system.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Membrana
/
Proteínas Bacterianas
Idioma:
En
Revista:
Trends Biochem Sci
/
Trends biochem. sci
/
Trends in biochemical sciences
Año:
2024
Tipo del documento:
Article
País de afiliación:
Suecia