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Advancing Inclusive Research (AIR) Site Alliance: Facilitating the inclusion of historically underrepresented people in oncology and ophthalmology clinical research.
Vidal, Gregory A; Chalela, Patricia; Curry, Andrea N; El-Rayes, Bassel; Halmos, Balazs; Herrera, Alex F; Kapoor, Kapil G; Kaur, Supreet; Mahadevan, Daruka; Mesa, Ruben; Ramirez, Amelie; Sleckman, Barry; Wagner, Alan L; Bhagat, Ruma; Brown, Isabel; Cruz, Leia; Funwie, Audrey; Highsmith, Quita; Richie, Nicole; McKenzie, Meghan.
Afiliación
  • Vidal GA; West Cancer Center & Research Institute, Germantown, TN, USA. Electronic address: gvidal@WESTCLINIC.com.
  • Chalela P; Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, USA.
  • Curry AN; West Cancer Center & Research Institute, Germantown, TN, USA.
  • El-Rayes B; O'Neal Comprehensive Cancer Center at UAB, Birmingham, AL, USA.
  • Halmos B; Montefiore Einstein Cancer Center, Bronx, NY, USA.
  • Herrera AF; City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
  • Kapoor KG; Wagner Kapoor Institute, Norfolk, VA, USA.
  • Kaur S; Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, USA.
  • Mahadevan D; Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, USA.
  • Mesa R; Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, USA.
  • Ramirez A; Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, USA.
  • Sleckman B; O'Neal Comprehensive Cancer Center at UAB, Birmingham, AL, USA.
  • Wagner AL; Wagner Kapoor Institute, Norfolk, VA, USA.
  • Bhagat R; Genentech, Inc., South San Francisco, CA, USA.
  • Brown I; Genentech, Inc., South San Francisco, CA, USA.
  • Cruz L; Genentech, Inc., South San Francisco, CA, USA.
  • Funwie A; Genentech, Inc., South San Francisco, CA, USA.
  • Highsmith Q; Genentech, Inc., South San Francisco, CA, USA.
  • Richie N; Genentech, Inc., South San Francisco, CA, USA.
  • McKenzie M; Genentech, Inc., South San Francisco, CA, USA.
Contemp Clin Trials ; 137: 107416, 2024 02.
Article en En | MEDLINE | ID: mdl-38109966
ABSTRACT

BACKGROUND:

The Advancing Inclusive Research (AIR) Site Alliance is composed of clinical research centers that partner with Genentech, a biotechnology company, to advance the representation of diverse patient populations in its oncology and ophthalmology clinical trials, test recruitment, and retention approaches and establish best practices to leverage across the industry to achieve health equity.

METHODS:

Through a data-driven selection process, Genentech identified 6 oncology and 3 ophthalmology partners that focus on reaching historically underrepresented patients in clinical trials and worked collaboratively to share knowledge and explore original ways of increasing clinical study access for every patient, including sites co-creation of a Protocol Entry Criteria Guideline with inclusion principles.

RESULTS:

For patients, three publicly available educational videos about clinical trials were created in multiple languages. The AIR Site Alliance has also defined invoiceable services for sites to enhance patient support; this has been built into the new study budget templates for sustainability. For healthcare professionals (HCPs), the first-of-its-kind AIR Educational Program was developed to focus on identifying and addressing bias and engaging historically underrepresented patient populations in trials. The sites also co-created videos for HCPs and patients on why advancing inclusive research matters. Over 16 regional health equity symposia have been delivered for patients, HCPs, and community leaders.

CONCLUSIONS:

This AIR Site Alliance is a model for other site alliances, including Kenya, South Africa, the United Kingdom, and Canada. Such alliances will build a robust and sustainable research ecosystem that includes diverse patient groups and encourages change across the healthcare system.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Personal de Salud / Investigación Biomédica Límite: Humans País/Región como asunto: Africa / America do norte Idioma: En Revista: Contemp Clin Trials Asunto de la revista: MEDICINA / TERAPEUTICA Año: 2024 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Personal de Salud / Investigación Biomédica Límite: Humans País/Región como asunto: Africa / America do norte Idioma: En Revista: Contemp Clin Trials Asunto de la revista: MEDICINA / TERAPEUTICA Año: 2024 Tipo del documento: Article