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Benign breast disease and breast cancer risk in African women: a case-control study.
Omoleye, Olasubomi J; Freeman, Jincong Q; Oluwasanu, Mojisola; Adeniji-Sofoluwe, Adenike; Woodard, Anna E; Aribisala, Benjamin S; Adejumo, Prisca O; Ntekim, Atara; Makumbi, Timothy; Ndom, Paul; Ajayi, IkeOluwapo O; Olopade, Olufunmilayo I; Huo, Dezheng.
Afiliación
  • Omoleye OJ; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Freeman JQ; Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, IL, USA.
  • Oluwasanu M; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.
  • Adeniji-Sofoluwe A; Department of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Woodard AE; Department of Radiology, University of Ibadan College of Medicine, Ibadan, Oyo State, Nigeria.
  • Aribisala BS; Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, IL, USA.
  • Adejumo PO; Data Science Institute, University of Chicago, Chicago, IL, USA.
  • Ntekim A; Department of Computer Science, Lagos State University, Ikeja, Lagos, Nigeria.
  • Makumbi T; Department of Nursing, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Ndom P; Department of Radiation Oncology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Ajayi IO; Department of Surgery, Mulago Hospital, Mulago, Kampala, Uganda.
  • Olopade OI; Hôpital Général Yaoundé, Yaoundé, Cameroon.
  • Huo D; Department of Epidemiology and Medical Statistics, University of Ibadan, Ibadan, Oyo State, Nigeria.
Cancer Causes Control ; 35(5): 787-798, 2024 May.
Article en En | MEDLINE | ID: mdl-38177455
ABSTRACT

PURPOSE:

To examine the association between benign breast disease (BBD) and breast cancer (BC) in a heterogeneous population of African women.

METHODS:

BC cases and controls were enrolled in three sub-Saharan African countries, Nigeria, Cameroon, and Uganda, between 1998 and 2018. Multivariable logistic regression was used to test the association between BBD and BC. Risk factors dually associated with BBD and BC were selected. Using a parametric mediation analysis model, we assessed if selected BC risk factors were mediated by BBD.

RESULTS:

Of 6,274 participants, 55.6% (3,478) were breast cancer cases. 360 (5.7%) self-reported BBD. Fibroadenoma (46.8%) was the most commonly reported BBD. Women with a self-reported history of BBD had greater odds of developing BC than those without (adjusted odds ratio [aOR] 1.47, 95% CI 1.13-1.91). Biopsy-confirmed BBD was associated with BC (aOR 2.25, 95% CI 1.26-4.02). BBD did not significantly mediate the effects of any of the selected BC risk factors.

CONCLUSIONS:

In this study, BBD was associated with BC and did not significantly mediate the effects of selected BC risk factors.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedades de la Mama / Neoplasias de la Mama Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Africa Idioma: En Revista: Cancer Causes Control Asunto de la revista: EPIDEMIOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedades de la Mama / Neoplasias de la Mama Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Africa Idioma: En Revista: Cancer Causes Control Asunto de la revista: EPIDEMIOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos