Bioassay-guided isolation and characterisation of α-glucosidase inhibitors from Sanghuangporus baumii.
Nat Prod Res
; : 1-9, 2024 Jan 05.
Article
en En
| MEDLINE
| ID: mdl-38179617
ABSTRACT
Bioassay-guided fractionation of the isopropanol extract of the medicinal mushroom Sanghuangporus baumii led to the isolation and characterisation of a new acorane-type sesquiterpenoid bauminene (1) and seven known compounds 2-8. The planar structure of 1 was elucidated on the basis of extensive spectroscopic analysis, including 1D, 2D NMR and HR-ESI-MS. The relative configuration of 1 was determined by a combination of ROESY experiment, density functional theory calculation of 13C NMR, and DP4+ probability analysis, while the absolute configuration of 1 was established by comparative electronic circular dichroism (ECD) spectra analysis. In the in vitro bioassay, compounds 1-8 exhibited potent to moderate α-glucosidase inhibitory activity with IC50 values ranging from 6.8 ± 0.68 to 221.4 ± 6.57 µM. The presences of these bioactive constituents in the sclerotia of S. baumii may be related to the use of the fungus as 'Sanghuang' for the adjuvant treatment of DM.
Texto completo:
1
Bases de datos:
MEDLINE
Idioma:
En
Revista:
Nat Prod Res
/
Nat. prod. res. (Online)
/
Natural product research (Online)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China