Diagnostic value of [ 68 Ga]Ga-Pentixafor PET/CT in malignant melanoma: a pilot study.
Nucl Med Commun
; 45(3): 221-228, 2024 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-38214076
ABSTRACT
OBJECTIVE:
To evaluate the diagnostic value of [ 68 Ga] Ga-Pentixafor in malignant melanoma patients.METHODS:
In this prospective study, patients with histology-proven melanoma were included and underwent [ 18 F]fluoro-D-glucose ([ 18 F]FDG) and [ 68 Ga] Ga-Pentixafor PET/computed tomography (CT) within a week. Suspicious lesions were interpreted as benign vs. malignant, and the corresponding semi-quantitative PET/CT parameters were recorded and compared.RESULTS:
Twelve consecutive melanoma patients (mean age 60â ±â 6) were included. Two patients were referred for initial staging, two for detecting recurrence and eight for evaluating the extent of metastases. Overall, [ 18 F]FDG PET/CT showed 236 tumoral lesions, including two primary tumors, two recurrent lesions, 29 locoregional metastases and 203 distant metastases. In [ 68 Ga]Ga-Pentixafor PET/CT, 101 tumoral lesions were detected, including two primary tumors, one recurrence, 16 locoregional metastases and 82 distant metastases. Notably, a documented brain metastasis was only visualized on [ 68 Ga]Ga-Pentixafor PET/CT images. Compared with [ 18 F]FDG, [ 68 Ga]Ga-Pentixafor PET/CT provided a 42% detection rate. Regarding semi-quantitative measures, the intensity of uptake and tumor-to-background ratios were significantly lower on [ 68 Ga]Ga-Pentixafor PET/CT [average maximum standard uptake value (SUV max ) of 2.72â ±â 1.33 vs. 11.41â ±â 14.79; P value <0.001 and 1.17â ±â 0.53 vs. 5.32â ±â 7.34; P value <0.001, respectively].CONCLUSION:
When comparing [ 68 Ga]Ga-Pentixafor PET/CT with [ 18 F]FDG PET/CT, not only did [ 68 Ga]Ga-Pentixafor PET/CT detect fewer lesions, but the intensity of uptake and the TBRs were also lower on [ 68 Ga]Ga-Pentixafor PET/CT. Thus, our results may indicate a limited potential of this novel tracer in cutaneous melanoma patients compared to [ 18 F]FDG PET/CT. Given the lower TBRs, applying this radiotracer in radioligand therapies is also questionable.
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Péptidos Cíclicos
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Neoplasias Cutáneas
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Complejos de Coordinación
/
Melanoma
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Aged
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Humans
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Middle aged
Idioma:
En
Revista:
Nucl Med Commun
Año:
2024
Tipo del documento:
Article