[Characteristics of myelodysplastic syndromes with der(1;7)(q10;p10)].
Rinsho Ketsueki
; 64(12): 1519-1522, 2023.
Article
en Ja
| MEDLINE
| ID: mdl-38220152
ABSTRACT
der(1;7)(q10;p10) is a derivative chromosome generated by an unbalanced translocation between chromosomes 1 and 7 during DNA replication. It was first described in 1980, over 40 years ago, in a case report of three patients with myelofibrosis and myeloid metaplasia. This unbalanced translocation has been identified as a characteristic entity within myeloid neoplasms. Recent clinical and genetic studies comparing der(1;7)(q10;p10)(+) against -7/del(7q) have revealed that patients with der(1;7)(q10;p10)(+) MDS have a better prognosis and a unique mutational profile. This review discusses the clinical and genetic features of der(1;7)(q10;p10)(+) myeloid neoplasms.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Síndromes Mielodisplásicos
/
Mielofibrosis Primaria
/
Trastornos Mieloproliferativos
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
Ja
Revista:
Rinsho Ketsueki
Año:
2023
Tipo del documento:
Article