Evaluation of robustness of optimization methods in breast intensity-modulated radiation therapy using TomoTherapy.
Phys Eng Sci Med
; 47(2): 465-475, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38265521
ABSTRACT
Intensity-modulated radiation therapy (IMRT) has become a popular choice for breast cancer treatment. We aimed to evaluate and compare the robustness of each optimization method used for breast IMRT using TomoTherapy. A retrospective analysis was performed on 10 patients with left breast cancer. For each optimization method (clipping, virtual bolus, and skin flash), a corresponding 50 Gy/25 fr plan was created in the helical and direct TomoTherapy modes. The dose-volume histogram parameters were compared after shifting the patients anteriorly and posteriorly. In the helical mode, when the patient was not shifted, the median D1cc (minimum dose delivered to 1 cc of the organ volume) of the breast skin for the clipping and virtual bolus plans was 52.2 (interquartile range 51.9-52.6) and 50.4 (50.1-50.8) Gy, respectively. After an anterior shift, D1cc of the breast skin for the clipping and virtual bolus plans was 56.0 (55.6-56.8) and 50.9 (50.5-51.3) Gy, respectively. When the direct mode was used without shifting the patient, D1cc of the breast skin for the clipping, virtual bolus, and skin flash plans was 52.6 (51.9-53.1), 53.4 (52.6-53.9), and 52.3 (51.7-53.0) Gy, respectively. After shifting anteriorly, D1cc of the breast skin for the clipping, virtual bolus, and skin flash plans was 55.6 (54.1-56.4), 52.4 (52.0-53.0), and 53.6 (52.6-54.6) Gy, respectively. The clipping method is not sufficient for breast IMRT. The virtual bolus and skin flash methods were more robust optimization methods according to our analyses.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Planificación de la Radioterapia Asistida por Computador
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Neoplasias de la Mama
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Radioterapia de Intensidad Modulada
Límite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Phys Eng Sci Med
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón