Effects of 90â¯dB pure tone exposure on auditory and cardio-cerebral system functions in macaque monkeys.
Environ Res
; 249: 118236, 2024 May 15.
Article
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| MEDLINE
| ID: mdl-38266893
ABSTRACT
Excessive noise exposure presents significant health risks to humans, affecting not just the auditory system but also the cardiovascular and central nervous systems. This study focused on three male macaque monkeys as subjects. 90â¯dB sound pressure level (SPL) pure tone exposure (frequency 500Hz, repetition rate 40Hz, 1â¯min per day, continuously exposed for 5 days) was administered. Assessments were performed before exposure, during exposure, immediately after exposure, and at 7-, 14-, and 28-days post-exposure, employing auditory brainstem response (ABR) tests, electrocardiograms (ECG), and electroencephalograms (EEG). The study found that the average threshold for the â
¤ wave in the right ear increased by around 30â¯dB SPL right after exposure (Pâ¯<â¯0.01) compared to pre-exposure. This elevation returned to normal within 7 days. The ECG results indicated that one of the macaque monkeys exhibited an RS-type QRS wave, and inverted T waves from immediately after exposure to 14 days, which normalized at 28 days. The other two monkeys showed no significant changes in their ECG parameters. Changes in EEG parameters demonstrated that main brain regions exhibited significant activation at 40Hz during noise exposure. After noise exposure, the power spectral density (PSD) in main brain regions, particularly those represented by the temporal lobe, exhibited a decreasing trend across all frequency bands, with no clear recovery over time. In summary, exposure to 90â¯dB SPL noise results in impaired auditory systems, aberrant brain functionality, and abnormal electrocardiographic indicators, albeit with individual variations. It has implications for establishing noise protection standards, although the precise mechanisms require further exploration by integrating pathological and behavioral indicators.
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Bases de datos:
MEDLINE
Asunto principal:
Potenciales Evocados Auditivos del Tronco Encefálico
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Electrocardiografía
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Electroencefalografía
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Ruido
Límite:
Animals
Idioma:
En
Revista:
Environ Res
Año:
2024
Tipo del documento:
Article