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High-fidelity intracellular imaging of multiple miRNAs via stimulus-responsive nanocarriers and catalytic hairpin assembly.
Zhang, Hongyan; Liu, Wendong; Zhang, Fanghua; Wu, Zhihan; Lu, Haijun; Hao, Zhe; Liu, Yu; Li, Xiyan; Zhang, Ruizhong; Zhang, Libing.
Afiliación
  • Zhang H; Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Tianjin University, Tianjin 300072, P. R. China. tjly@tju.edu.cn.
  • Liu W; Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Tianjin University, Tianjin 300072, P. R. China. tjly@tju.edu.cn.
  • Zhang F; Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Tianjin University, Tianjin 300072, P. R. China. tjly@tju.edu.cn.
  • Wu Z; Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Tianjin University, Tianjin 300072, P. R. China. tjly@tju.edu.cn.
  • Lu H; Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Tianjin University, Tianjin 300072, P. R. China. tjly@tju.edu.cn.
  • Hao Z; Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Tianjin University, Tianjin 300072, P. R. China. tjly@tju.edu.cn.
  • Liu Y; Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Tianjin University, Tianjin 300072, P. R. China. tjly@tju.edu.cn.
  • Li X; Institute of Photoelectronic Thin Film Devices and Technology, Solar Energy Conversion Center, Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin, Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education, Nankai University, Tianjin 30035
  • Zhang R; Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Tianjin University, Tianjin 300072, P. R. China. tjly@tju.edu.cn.
  • Zhang L; Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Tianjin University, Tianjin 300072, P. R. China. tjly@tju.edu.cn.
Chem Commun (Camb) ; 60(17): 2377-2380, 2024 Feb 22.
Article en En | MEDLINE | ID: mdl-38321956
ABSTRACT
An advanced nanoplatform was developed by integrating catalytic hairpin assembly (CHA) with glutathione-responsive nanocarriers, enabling superior imaging of dual cancer-related miRNAs. Two distinct CHA circuits for the sensing of miRNA-21 and miRNA-155 were functionalized on biodegraded MnO2. In the presence of GSH and the corresponding miRNAs, the degraded MnO2 released the DNA cargos, activating the CHA circuits and recovering the fluorescence. This approach offers a reliable sensing performance with highly selective cell-identification capacity, positioning it as a pivotal tool for imaging multiple biomarkers in living cells.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Técnicas Biosensibles / ADN Catalítico / MicroARNs Idioma: En Revista: Chem Commun (Camb) / Chem. commun. (Lond., 1996, Online) / Chemical communications (London. 1996. Online) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Técnicas Biosensibles / ADN Catalítico / MicroARNs Idioma: En Revista: Chem Commun (Camb) / Chem. commun. (Lond., 1996, Online) / Chemical communications (London. 1996. Online) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article