Ligand-Enabled Copper-Mediated Radioiodination of Arenes.
Org Lett
; 26(7): 1528-1532, 2024 Feb 23.
Article
en En
| MEDLINE
| ID: mdl-38335124
ABSTRACT
The discovery of a copper precatalyst that facilitates the key mechanistic steps of arene halodeboronation has allowed a step change in the synthesis of radioiodine-containing arenes. The active precatalyst [Cu(OAc)(phen)2]OAc was shown to perform room temperature radio-iododeboronation of aryl boronic acids with 1-2 mol % loadings and 10 min reaction times. These mild conditions enable particularly clean reactions, as demonstrated with the efficient preparation of the radiopharmaceutical and SPECT tracer, meta-iodobenzylguanidine (MIBG).
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MEDLINE
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En
Revista:
Org Lett
/
Org. lett
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Organic letters
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article