Your browser doesn't support javascript.
loading
Olanzapine's effects on hypothalamic transcriptomics and kinase activity.
Pereira, Sandra; Castellani, Laura N; Kowalchuk, Chantel; Alganem, Khaled; Zhang, Xiaolu; Ryan, William G; Singh, Raghunath; Wu, Sally; Au, Emily; Asgariroozbehani, Roshanak; Agarwal, Sri Mahavir; Giacca, Adria; Mccullumsmith, Robert E; Hahn, Margaret K.
Afiliación
  • Pereira S; Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada.
  • Castellani LN; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Kowalchuk C; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Alganem K; Department of Neurosciences, University of Toledo, Toledo, OH, USA.
  • Zhang X; Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
  • Ryan WG; Department of Neurosciences, University of Toledo, Toledo, OH, USA.
  • Singh R; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Wu S; Centre for Addiction and Mental Health, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
  • Au E; Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada.
  • Asgariroozbehani R; Centre for Addiction and Mental Health, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
  • Agarwal SM; Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Banting & Best Diabetes Centre, Toronto, ON, Canada.
  • Giacca A; Department of Physiology, University of Toronto, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada; Banting & Best Diabetes Centre, Toronto, ON, Canada.
  • Mccullumsmith RE; Department of Neurosciences, University of Toledo, Toledo, OH, USA; ProMedica, Neuroscience Institute, Toledo, OH, USA.
  • Hahn MK; Centre for Addiction and Mental Health, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Banting & Best Dia
Psychoneuroendocrinology ; 163: 106987, 2024 May.
Article en En | MEDLINE | ID: mdl-38340539
ABSTRACT
Olanzapine is a second-generation antipsychotic that disrupts metabolism and is associated with an increased risk of type 2 diabetes. The hypothalamus is a key region in the control of whole-body metabolic homeostasis. The objective of the current study was to determine how acute peripheral olanzapine administration affects transcription and serine/threonine kinase activity in the hypothalamus. Hypothalamus samples from rats were collected following the pancreatic euglycemic clamp, thereby allowing us to study endpoints under steady state conditions for plasma glucose and insulin. Olanzapine stimulated pathways associated with inflammation, but diminished pathways associated with the capacity to combat endoplasmic reticulum stress and G protein-coupled receptor activity. These pathways represent potential targets to reduce the incidence of type 2 diabetes in patients taking antipsychotics.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antipsicóticos / Diabetes Mellitus Tipo 2 Límite: Animals / Humans Idioma: En Revista: Psychoneuroendocrinology Año: 2024 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antipsicóticos / Diabetes Mellitus Tipo 2 Límite: Animals / Humans Idioma: En Revista: Psychoneuroendocrinology Año: 2024 Tipo del documento: Article País de afiliación: Canadá