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Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus.
Hirasawa, Yusuke; Kase, Ayaka; Okamoto, Akie; Suzuki, Keigo; Hiroki, Mizuki; Kaneda, Toshio; Uchiyama, Nahoko; Morita, Hiroshi.
Afiliación
  • Hirasawa Y; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan. y-hirasawa@hoshi.ac.jp.
  • Kase A; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan.
  • Okamoto A; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan.
  • Suzuki K; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan.
  • Hiroki M; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan.
  • Kaneda T; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan.
  • Uchiyama N; National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan.
  • Morita H; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan. moritah@hoshi.ac.jp.
J Nat Med ; 78(2): 382-392, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38347371
ABSTRACT
A new dimeric indole alkaloid, vincazalidine A consisting of an aspidosperma type and a modified iboga type with 1-azatricyclo ring system consisting of one azepane and two piperidine rings coupled with an oxazolidine ring was isolated from Catharanthus roseus, and the structure including absolute stereochemistry was elucidated on the basis of spectroscopic data as well as DP4 statistical analysis. Vincazalidine A induced G2 arrest and subsequent apoptosis in human lung carcinoma cell line, A549 cells.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aspidosperma / Catharanthus / Alcaloides / Antineoplásicos Límite: Humans Idioma: En Revista: J Nat Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aspidosperma / Catharanthus / Alcaloides / Antineoplásicos Límite: Humans Idioma: En Revista: J Nat Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: Japón