Sex Differences in Association of Physical Activity With All-Cause and Cardiovascular Mortality.
J Am Coll Cardiol
; 83(8): 783-793, 2024 Feb 27.
Article
en En
| MEDLINE
| ID: mdl-38383092
ABSTRACT
BACKGROUND:
Although physical activity is widely recommended for reducing cardiovascular and all-cause mortality risks, female individuals consistently lag behind male individuals in exercise engagement.OBJECTIVES:
The goal of this study was to evaluate whether physical activity derived health benefits may differ by sex.METHODS:
In a prospective study of 412,413 U.S. adults (55% female, age 44 ± 17 years) who provided survey data on leisure-time physical activity, we examined sex-specific multivariable-adjusted associations of physical activity measures (frequency, duration, intensity, type) with all-cause and cardiovascular mortality from 1997 through 2019.RESULTS:
During 4,911,178 person-years of follow-up, there were 39,935 all-cause deaths including 11,670 cardiovascular deaths. Regular leisure-time physical activity compared with inactivity was associated with 24% (HR 0.76; 95% CI 0.73-0.80) and 15% (HR 0.85; 95% CI 0.82-0.89) lower risk of all-cause mortality in women and men, respectively (Wald F = 12.0, sex interaction P < 0.001). Men reached their maximal survival benefit of HR 0.81 from 300 min/wk of moderate-to-vigorous physical activity, whereas women achieved similar benefit at 140 min/wk and then continued to reach a maximum survival benefit of HR 0.76 also at â¼300 min/wk. Sex-specific findings were similar for cardiovascular death (Wald F = 20.1, sex interaction P < 0.001) and consistent across all measures of aerobic activity as well as muscle strengthening activity (Wald F = 6.7, sex interaction P = 0.009).CONCLUSIONS:
Women compared with men derived greater gains in all-cause and cardiovascular mortality risk reduction from equivalent doses of leisure-time physical activity. These findings could enhance efforts to close the "gender gap" by motivating especially women to engage in any regular leisure-time physical activity.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
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Actividades Recreativas
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Am Coll Cardiol
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J. Am. Coll. Cardiol
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Journal of the American College of Cardiology
Año:
2024
Tipo del documento:
Article