Development of on-DNA Formation of Benzofuran for DNA-Encoded Library Synthesis.
Org Lett
; 26(8): 1688-1693, 2024 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-38385779
ABSTRACT
Using a novel homologation-heterocyclization cascade, the on-DNA synthesis of benzofurans from aldehydes has been developed. The methodology, based on an innovative use of the Seyferth-Gilbert homologation, followed by a high yielding Sonogashira coupling in situ intramolecular cyclization one-pot, two-step reaction, provides a powerful and unique pathway for DNA-encoded library (DEL) synthesis of a wide array of pharmaceutically relevant benzofuran-based scaffolds.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Benzofuranos
Idioma:
En
Revista:
Org Lett
/
Org. lett
/
Organic letters
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article