Two previously undescribed cholestanol saponins from the rhizomes of Paris fargesii var. petiolata.
Fitoterapia
; 175: 105881, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38438054
ABSTRACT
Two previously undescribed cholestanol saponins, parpetiosides F - G (1-2), and six known analogs (3-8) were isolated from the rhizomes of Paris fargesii var. petiolata. Their structures were elucidated by extensive spectroscopic data analysis and chemical methods. Compound 1 was a rare 6/6/6/5/5 fused-rings cholestanol saponin with disaccharide moiety linked at C-26 of aglycone which was hardly seen in genus Paris. All of these compounds were discovered in this plant for the first time. In addition, the cytotoxicities of saponins (1-8) against three human cancer cell lines (U87, HepG2 and SGC-7901) were evaluated by CCK-8 method, and saponins 5-8 displayed certain cytotoxicities. The strong interactions between saponins 5-8 and SCUBE3, an oncogene for glioma cells, were displayed by molecular docking.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Saponinas
/
Colestanol
/
Rizoma
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Simulación del Acoplamiento Molecular
/
Antineoplásicos Fitogénicos
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Fitoterapia
Año:
2024
Tipo del documento:
Article
País de afiliación:
China