Optical coherence tomography biomarkers indicating visual enhancement in diabetic macular edema resolved through anti-VEGF therapy: OCT biomarkers in resolved DME.
Photodiagnosis Photodyn Ther
; 46: 104042, 2024 Apr.
Article
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| MEDLINE
| ID: mdl-38460657
ABSTRACT
PURPOSE:
to investigate the structural features and extended visual results in eyes affected by diabetic retinopathy (DR) and diabetic macular edema (DME) that have been successfully treated with anti-vascular endothelial growth factor (VEGF) therapy.METHODS:
Individuals (39 eyes of 39 patients) who had undergone long-term follow-up and demonstrated evidence of resolved DME after at least 2 years of follow-up following the initiation of anti-VEGF therapy were included. During the ""study visit"", structural OCT scans were examined to assess qualitative features indicative of neuroretina or retinal pigment epithelium distress. Additionally, a quantitative assessment of the inner and outer retinal thicknesses was conducted for topographical analysis.RESULTS:
The most robust qualitative association observed with BCVA at the "study visit" was linked to the presence of DRIL (p = 0.043) and the appearance of the ELM. (p = 0.045). Regarding quantitative parameters, a strong correlation was noted between the visual acuity during the "study visit" and the foveal and parafoveal thicknesses of both the inner and outer retina (p < 0.001).CONCLUSIONS:
Changes in the status of ELM, the presence of DRIL, and the thicknesses of the foveal and parafoveal regions can act as OCT biomarkers, signifying prolonged visual improvements in eyes that have experienced resolved DME after undergoing anti-VEGF therapy.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Agudeza Visual
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Edema Macular
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Inhibidores de la Angiogénesis
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Factor A de Crecimiento Endotelial Vascular
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Tomografía de Coherencia Óptica
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Retinopatía Diabética
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Photodiagnosis Photodyn Ther
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
TERAPEUTICA
Año:
2024
Tipo del documento:
Article