Motoric Cognitive Risk Syndrome and the Risk of Incident Dementia: A Systematic Review and Meta-Analysis of Cohort Studies.
Gerontology
; 70(5): 479-490, 2024.
Article
en En
| MEDLINE
| ID: mdl-38461816
ABSTRACT
BACKGROUND:
Epidemiologic studies have indicated an association of motoric cognitive risk syndrome (MCR), a pre-dementia stage characterized by the presence of cognitive complaints and a slow gait, with increased risk of incident dementia.OBJECTIVES:
We aimed to clarify this association using meta-analysis.METHODS:
We systematically searched the PubMed, Embase, and Web of Science databases up to December 2022 for relevant studies that investigated the association between MCR and incident all-cause dementia and Alzheimer's disease (AD). The random-effects model was used to determine a pooled-effect estimate of the association.RESULTS:
We identified seven articles that corresponded with nine cohort studies investigating the association between MCR and the risk of dementia. Pooled analysis showed that MCR was associated with a significantly increased risk of incident all-cause dementia (HR = 2.28; 95% CI 1.90-2.73) and AD (HR = 2.05; 95% CI 1.61-2.61). Sensitivity analysis showed that there was no evidence that individual studies influenced the pooled-effect estimate, verifying the robustness of the results.CONCLUSIONS:
Our results confirm that MCR is an independent risk factor of incident all-cause dementia and AD. Future studies are needed to better understand the mechanisms underlying this association.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Demencia
/
Enfermedad de Alzheimer
Límite:
Aged
/
Humans
Idioma:
En
Revista:
Gerontology
Año:
2024
Tipo del documento:
Article
País de afiliación:
China