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Cell sorting by active forces in a phase-field model of cell monolayers.
Graham, James N; Zhang, Guanming; Yeomans, Julia M.
Afiliación
  • Graham JN; Rudolf Peierls Centre for Theoretical Physics, Parks Road, University of Oxford, Oxford, OX1 3PU, UK. james.graham@physics.ox.ac.uk.
  • Zhang G; Center for Soft Matter Research, Department of Physics, New York University, New York 10003, USA.
  • Yeomans JM; Simons Center for Computational Physical Chemistry, Department of Chemistry, New York University, New York 10003, USA.
Soft Matter ; 20(13): 2955-2960, 2024 Mar 27.
Article en En | MEDLINE | ID: mdl-38469688
ABSTRACT
Cell sorting, the segregation of cells with different properties into distinct domains, is a key phenomenon in biological processes such as embryogenesis. We use a phase-field model of a confluent cell layer to study the role of activity in cell sorting. We find that a mixture of cells with extensile or contractile dipolar activity, and which are identical apart from their activity, quickly sort into small, elongated patches which then grow slowly in time. We interpret the sorting as driven by the different diffusivity of the extensile and contractile cells, mirroring the ordering of Brownian particles connected to different hot and cold thermostats. We check that the free energy is not changed by either partial or complete sorting, thus confirming that activity can be responsible for the ordering even in the absence of thermodynamic mechanisms.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Termodinámica / Fenómenos Fisiológicos Celulares Idioma: En Revista: Soft Matter Año: 2024 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Termodinámica / Fenómenos Fisiológicos Celulares Idioma: En Revista: Soft Matter Año: 2024 Tipo del documento: Article