Insights into LINE-1 reverse transcription guide therapy development.
Trends Cancer
; 10(4): 286-288, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38499453
ABSTRACT
Subsets of long interspersed nuclear element 1 (LINE-1) retrotransposons can 'retrotranspose' throughout the human genome at a cost to host cell fitness, as observed in some cancers. Pharmacological inhibition of LINE-1 retrotransposition requires a comprehensive understanding of the LINE-1 ORF2p reverse transcriptase. Two recent publications, by Thawani et al. and Baldwin et al., report structures of LINE-1 ORF2p and address long-standing mechanistic gaps regarding LINE-1 retrotransposition. Both studies will be critical to design new specific inhibitors of the LINE-1 ORF2p reverse transcriptase.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Elementos de Nucleótido Esparcido Largo
/
Transcripción Reversa
Límite:
Humans
Idioma:
En
Revista:
Trends Cancer
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos