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The ABCB1 and ABCG2 efflux transporters limit brain disposition of the SYK inhibitors entospletinib and lanraplenib.
Loos, Nancy H C; Sparidans, Rolf W; Heydari, Paniz; Bui, Viët; Lebre, Maria C; Beijnen, Jos H; Schinkel, Alfred H.
Afiliación
  • Loos NHC; The Netherlands Cancer Institute, Division of Pharmacology, Amsterdam, the Netherlands.
  • Sparidans RW; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacology, Utrecht, the Netherlands.
  • Heydari P; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacology, Utrecht, the Netherlands.
  • Bui V; The Netherlands Cancer Institute, Division of Pharmacology, Amsterdam, the Netherlands.
  • Lebre MC; The Netherlands Cancer Institute, Division of Pharmacology, Amsterdam, the Netherlands.
  • Beijnen JH; The Netherlands Cancer Institute, Division of Pharmacology, Amsterdam, the Netherlands; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht, the Netherlands; The Netherlands Cancer Institute, Division of P
  • Schinkel AH; The Netherlands Cancer Institute, Division of Pharmacology, Amsterdam, the Netherlands. Electronic address: a.schinkel@nki.nl.
Toxicol Appl Pharmacol ; 485: 116911, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38527694
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirazinas / Encéfalo / Morfolinas / Inhibidores de Proteínas Quinasas / Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2 / Indazoles Límite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirazinas / Encéfalo / Morfolinas / Inhibidores de Proteínas Quinasas / Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2 / Indazoles Límite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos