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Bioinformatics-Guided Reconstitution of Biosynthetic Machineries of Fungal Eremophilane Sesquiterpenes.
Sato, Yoshiro; Shi, Xinge; Ye, Ying; Domon, Saori; Takino, Junya; Ozaki, Taro; Liu, Chengwei; Oikawa, Hideaki; Minami, Atsushi.
Afiliación
  • Sato Y; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
  • Shi X; Key Laboratory for Enzyme and Enzyme-like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, Harbin 150040, China.
  • Ye Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Domon S; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
  • Takino J; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
  • Ozaki T; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
  • Liu C; Key Laboratory for Enzyme and Enzyme-like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, Harbin 150040, China.
  • Oikawa H; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
  • Minami A; Innovation Center of Marine Biotechnology and Pharmaceuticals, School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
ACS Chem Biol ; 19(4): 861-865, 2024 04 19.
Article en En | MEDLINE | ID: mdl-38568215
ABSTRACT
Eremophilanes exhibit diverse biological activities and chemical structures. This study reports the bioinformatics-guided reconstitution of the biosynthetic machinery of fungal eremophilanes, eremofortin C and sporogen-AO1, to elucidate their biosynthetic pathways. Their biosyntheses include P450-catalyzed multistep oxidation and enzyme-catalyzed isomerization by the DUF3237 family protein. Successful characterization of six P450s enabled us to discuss the functions of eremophilane P450s in putative eremophilane biosynthetic gene clusters, providing opportunities to understand the oxidative modification pathways of fungal eremophilanes.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sesquiterpenos Idioma: En Revista: ACS Chem Biol Año: 2024 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sesquiterpenos Idioma: En Revista: ACS Chem Biol Año: 2024 Tipo del documento: Article País de afiliación: Japón