Association of serum five heavy metals level with all-cause and cause-specific mortality: a large population-based cohort study.
J Environ Sci Health A Tox Hazard Subst Environ Eng
; 59(3): 130-154, 2024.
Article
en En
| MEDLINE
| ID: mdl-38613167
ABSTRACT
The study aimed to explore the association between five heavy metals exposure (Cadmium, Lead, Mercury, Manganese, and Selenium) and mortality [all-cause, cardiovascular disease (CVD), and cancer-related]. We integrated the data into the National Health and Nutrition Examination Survey from 2011 to 2018 years. A total of 16,092 participants were recruited. The link between heavy metals exposure and mortality was analyzed by constructing a restricted cubic spline (RCS) curve, Cox proportional hazard regression model, and subgroup analysis. The RCS curve was used to show a positive linear relationship between Cadmium, Lead, and all-cause mortality. In contrast, there was a negative linear correlation between Mercury and all-cause mortality. Additionally, Manganese and Selenium also had a J-shaped and L-shaped link with all-cause mortality. The positive linear, positive linear, negative liner, J-shaped, and L-shaped relationships were observed for Cadmium, Lead, Mercury, Manganese, and Selenium and CVD mortality, respectively. Cadmium, Lead, Mercury, and Selenium were observed to exhibit positive linear, U-shaped, negative linear, and L-shaped relationships with cancer-related mortality, respectively. There was an increase and then a decrease in the link between Manganese and cancer-related morality. This study revealed the correlation between the content of different elements and different types of mortality in the U.S. general population.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Selenio
/
Enfermedades Cardiovasculares
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Metales Pesados
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Mercurio
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Neoplasias
Límite:
Humans
Idioma:
En
Revista:
J Environ Sci Health A Tox Hazard Subst Environ Eng
/
J. environ. sci. health A tox. hazard. subst. environ. eng
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Hazardous substances & environmental engineering
Asunto de la revista:
TOXICOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China