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When Should I Get My Next COVID-19 Vaccine? Data From the Surveillance of Responses to COVID-19 Vaccines in Systemic Immune-Mediated Inflammatory Diseases (SUCCEED) Study.
Bowdish, Dawn M E; Chandran, Vinod; Hitchon, Carol A; Kaplan, Gilaad G; Avina-Zubieta, J Antonio; Fortin, Paul R; Larché, Maggie J; Boire, Gilles; Gingras, Anne-Claude; Dayam, Roya M; Colmegna, Ines; Lukusa, Luck; Lee, Jennifer L F; Richards, Dawn P; Pereira, Daniel; Watts, Tania H; Silverberg, Mark S; Bernstein, Charles N; Lacaille, Diane; Benoit, Jenna; Kim, John; Lalonde, Nadine; Gunderson, Janet; Allard-Chamard, Hugues; Roux, Sophie; Quan, Joshua; Hracs, Lindsay; Turnbull, Elizabeth; Valerio, Valeria; Bernatsky, Sasha.
Afiliación
  • Bowdish DME; D.M.E. Bowdish, PhD, J. Benoit, Department of Medicine, McMaster University, Hamilton, Ontario.
  • Chandran V; V. Chandran, MD, PhD, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario.
  • Hitchon CA; C.A. Hitchon, MD, MSc, C.N. Bernstein, MD, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba.
  • Kaplan GG; G.G. Kaplan, MD, MPH, J. Quan, MSc, L. Hracs, PhD, Division of Gastroenterology and Hepatology, Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta.
  • Avina-Zubieta JA; J.A. Avina-Zubieta, MD, PhD, D. Lacaille, MD, MHSc, Arthritis Research Canada, and Division of Rheumatology, University of British Columbia, Vancouver, British Columbia.
  • Fortin PR; P.R. Fortin, MD, MPH, Centre de Recherche Arthrite, Division of Rheumatology, Department of Medicine, CHU de Québec - Université Laval, Quebec City, Quebec.
  • Larché MJ; M.J. Larché, MD, PhD, Division of Rheumatology, Department of Medicine, McMaster University, Hamilton, Ontario.
  • Boire G; G. Boire, MD, MSc, H. Allard-Chamard, MD, PhD, S. Roux, MD, PhD, Division of Rheumatology, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec.
  • Gingras AC; A.C. Gingras, PhD, R.M. Dayam, PhD, Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Sinai Health, Toronto, Ontario.
  • Dayam RM; A.C. Gingras, PhD, R.M. Dayam, PhD, Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Sinai Health, Toronto, Ontario.
  • Colmegna I; I. Colmegna, MD, S. Bernatsky, MD, PhD, The Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec, and Department of Medicine, Division of Rheumatology, McGill University, Montreal, Quebec.
  • Lukusa L; L. Lukusa, MSc, J.L.F. Lee, BSc, E. Turnbull, RN, V. Valerio, MD, The Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec.
  • Lee JLF; L. Lukusa, MSc, J.L.F. Lee, BSc, E. Turnbull, RN, V. Valerio, MD, The Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec.
  • Richards DP; D.P. Richards, PhD, N. Lalonde, BSc, J. Gunderson, BEd, Canadian Arthritis Patient Alliance, Toronto, Ontario.
  • Pereira D; D. Pereira, BSc, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario.
  • Watts TH; T.H. Watts, PhD, Department of Immunology, University of Toronto, Toronto, Ontario.
  • Silverberg MS; M.S. Silverberg, MD, PhD, Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Sinai Health, and Zane Cohen Center for Digestive Diseases, Division of Gastroenterology, Mount Sinai Hospital, Sinai Health, Toronto, Ontario.
  • Bernstein CN; C.A. Hitchon, MD, MSc, C.N. Bernstein, MD, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba.
  • Lacaille D; J.A. Avina-Zubieta, MD, PhD, D. Lacaille, MD, MHSc, Arthritis Research Canada, and Division of Rheumatology, University of British Columbia, Vancouver, British Columbia.
  • Benoit J; D.M.E. Bowdish, PhD, J. Benoit, Department of Medicine, McMaster University, Hamilton, Ontario.
  • Kim J; J. Kim, PhD, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
  • Lalonde N; D.P. Richards, PhD, N. Lalonde, BSc, J. Gunderson, BEd, Canadian Arthritis Patient Alliance, Toronto, Ontario.
  • Gunderson J; D.P. Richards, PhD, N. Lalonde, BSc, J. Gunderson, BEd, Canadian Arthritis Patient Alliance, Toronto, Ontario.
  • Allard-Chamard H; G. Boire, MD, MSc, H. Allard-Chamard, MD, PhD, S. Roux, MD, PhD, Division of Rheumatology, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec.
  • Roux S; G. Boire, MD, MSc, H. Allard-Chamard, MD, PhD, S. Roux, MD, PhD, Division of Rheumatology, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec.
  • Quan J; G.G. Kaplan, MD, MPH, J. Quan, MSc, L. Hracs, PhD, Division of Gastroenterology and Hepatology, Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta.
  • Hracs L; G.G. Kaplan, MD, MPH, J. Quan, MSc, L. Hracs, PhD, Division of Gastroenterology and Hepatology, Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta.
  • Turnbull E; L. Lukusa, MSc, J.L.F. Lee, BSc, E. Turnbull, RN, V. Valerio, MD, The Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec.
  • Valerio V; L. Lukusa, MSc, J.L.F. Lee, BSc, E. Turnbull, RN, V. Valerio, MD, The Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec.
  • Bernatsky S; I. Colmegna, MD, S. Bernatsky, MD, PhD, The Research Institute of the McGill University Health Center, McGill University, Montreal, Quebec, and Department of Medicine, Division of Rheumatology, McGill University, Montreal, Quebec; sasha.bernatsky@mcgill.ca.
J Rheumatol ; 51(7): 721-727, 2024 Jul 01.
Article en En | MEDLINE | ID: mdl-38621797
ABSTRACT

OBJECTIVE:

To determine how serologic responses to coronavirus disease 2019 (COVID-19) vaccination and infection in immune-mediated inflammatory disease (IMID) are affected by time since last vaccination and other factors.

METHODS:

Post-COVID-19 vaccination, data, and dried blood spots or sera were collected from adults with rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis and spondylarthritis, and psoriasis and psoriatic arthritis. The first sample was collected at enrollment, then at 2 to 4 weeks and 3, 6, and 12 months after the latest vaccine dose. Multivariate generalized estimating equation regressions (including medications, demographics, and vaccination history) evaluated serologic response, based on log-transformed anti-receptor-binding domain (RBD) IgG titers; we also measured antinucleocapsid (anti-N) IgG.

RESULTS:

Positive associations for log-transformed anti-RBD titers were seen with female sex, number of doses, and self-reported COVID-19 infections in 2021 to 2023. Negative associations were seen with prednisone, anti-tumor necrosis factor agents, and rituximab. Over the 2021-2023 period, most (94%) of anti-N positivity was associated with a self-reported infection in the 3 months prior to testing. From March 2021 to February 2022, anti-N positivity was present in 5% to 15% of samples and was highest in the post-Omicron era, with antinucleocapsid positivity trending to 30% to 35% or higher as of March 2023. Anti-N positivity in IMID remained lower than Canada's general population seroprevalence (> 50% in 2022 and > 75% in 2023). Time since last vaccination was negatively associated with log-transformed anti-RBD titers, particularly after 210 days.

CONCLUSION:

Ours is the first pan-Canadian IMID assessment of how vaccine history and other factors affect serologic COVID-19 vaccine responses. These findings may help individuals personalize vaccination decisions, including consideration of additional vaccination when > 6 months has elapsed since last COVID-19 vaccination/infection.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Vacunas contra la COVID-19 / COVID-19 Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Rheumatol Año: 2024 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Vacunas contra la COVID-19 / COVID-19 Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Rheumatol Año: 2024 Tipo del documento: Article