Emerging roles of circular RNAs in nasopharyngeal carcinoma: functions and implications.
Cell Death Discov
; 10(1): 192, 2024 Apr 25.
Article
en En
| MEDLINE
| ID: mdl-38664370
ABSTRACT
Nasopharyngeal carcinoma (NPC) is a distinct malignancy primarily prevalent in Southern China and Southeast Asia. Circular RNAs (circRNAs), a class of non-coding RNAs, are evolutionarily conserved and exhibit remarkable stability. Their dysregulation has been observed in various cancers, including NPC. In this review, we investigate the pivotal role of circRNAs in NPC, focusing specifically on their involvement in tumor proliferation, apoptosis, metastasis, angiogenesis, stemness, metabolism, and the tumor microenvironment. We highlight the diagnostic and prognostic potential of circRNAs in NPC, emphasizing their utility as biomarkers for early detection, disease monitoring, and prediction of treatment outcomes. Additionally, we explore the therapeutic implications of circRNAs in NPC, highlighting their potential for targeted therapies.
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Bases de datos:
MEDLINE
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En
Revista:
Cell Death Discov
Año:
2024
Tipo del documento:
Article
País de afiliación:
China