CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age.
Nat Commun
; 15(1): 3387, 2024 Apr 29.
Article
en En
| MEDLINE
| ID: mdl-38684663
ABSTRACT
Influenza B viruses (IBVs) cause substantive morbidity and mortality, and yet immunity towards IBVs remains understudied. CD8+ T-cells provide broadly cross-reactive immunity and alleviate disease severity by recognizing conserved epitopes. Despite the IBV burden, only 18 IBV-specific T-cell epitopes restricted by 5 HLAs have been identified currently. A broader array of conserved IBV T-cell epitopes is needed to develop effective cross-reactive T-cell based IBV vaccines. Here we identify 9 highly conserved IBV CD8+ T-cell epitopes restricted to HLA-B*0702, HLA-B*0801 and HLA-B*3501. Memory IBV-specific tetramer+CD8+ T-cells are present within blood and tissues. Frequencies of IBV-specific CD8+ T-cells decline with age, but maintain a central memory phenotype. HLA-B*0702 and HLA-B*0801-restricted NP30-38 epitope-specific T-cells have distinct T-cell receptor repertoires. We provide structural basis for the IBV HLA-B*0702-restricted NS1196-206 (11-mer) and HLA-B*0702-restricted NP30-38 epitope presentation. Our study increases the number of IBV CD8+ T-cell epitopes, and defines IBV-specific CD8+ T-cells at cellular and molecular levels, across tissues and age.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Virus de la Influenza B
/
Linfocitos T CD8-positivos
/
Epítopos de Linfocito T
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Gripe Humana
Límite:
Adolescent
/
Adult
/
Aged
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Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Nat Commun
Asunto de la revista:
BIOLOGIA
/
CIENCIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Australia