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The Roles of Neuropeptide Y in Respiratory Disease Pathogenesis via the Airway Immune Response.
Itano, Junko; Kiura, Katsuyuki; Maeda, Yoshinobu; Miyahara, Nobuaki.
Afiliación
  • Itano J; Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
  • Kiura K; Department of Allergy and Respiratory Medicine, National Hospital Organization Minami-Okayama Medical Center.
  • Maeda Y; Department of Allergy and Respiratory Medicine, Okayama University Hospital.
  • Miyahara N; Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
Acta Med Okayama ; 78(2): 95-106, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38688827
ABSTRACT
The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neuropéptido Y / Receptores de Neuropéptido Y Límite: Animals / Humans Idioma: En Revista: Acta Med Okayama Año: 2024 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neuropéptido Y / Receptores de Neuropéptido Y Límite: Animals / Humans Idioma: En Revista: Acta Med Okayama Año: 2024 Tipo del documento: Article