Genetic prediction of micronutrient levels and the risk of colorectal polyps: A mendelian randomization study.
Clin Nutr
; 43(6): 1405-1413, 2024 Jun.
Article
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| MEDLINE
| ID: mdl-38691983
ABSTRACT
OBJECTIVE:
Previous epidemiological and experimental studies have yielded conflicting results regarding the influence of human micronutrient levels on the risk of colorectal polyps (CP). In our study, we conducted a two-sample Mendelian randomization (MR) investigation to probe the link between 13 human micronutrients (calcium, selenium, magnesium, phosphorus, folate, vitamins B-6, B-12, C, D, beta-carotene, iron, zinc, and copper) and the genetic susceptibility to CP.METHODS:
Summary statistics for CP (n = 463,010) were obtained from pan-European genome-wide association studies, and instrumental variables for 13 micronutrients were screened from published genome-wide association studies (GWAS). After selecting suitable instrumental variables, we performed a two-sample MR study, deploying sensitivity analyses to judge heterogeneity and pleiotropy, using inverse variance weighted methods as our primary estimation tool.RESULTS:
Our study identified that a genetic predisposition to elevated toenail and circulating selenium or serum ß-carotene concentrations lowers the risk of CP occurrence. However, no statistically significant association was observed between the other 11 micronutrients and the risk of CP.CONCLUSION:
The study findings provide evidence that the micronutrient selenium and ß-carotene may confer protective effects against the development of CP.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Selenio
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Pólipos del Colon
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Micronutrientes
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Predisposición Genética a la Enfermedad
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Estudio de Asociación del Genoma Completo
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Análisis de la Aleatorización Mendeliana
Límite:
Humans
Idioma:
En
Revista:
Clin Nutr
Año:
2024
Tipo del documento:
Article