DDX21: The link between m<sup>6</sup>A and R-loops.

Lavergne, Guillaume; Roignant, Jean-Yves

DDX21: The link between m⁶A and R-loops.

Lavergne, Guillaume; Roignant, Jean-Yves.

Afiliación

Lavergne G; Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland.
Roignant JY; Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz, Staudingerweg 5, 55128 Mainz, Germany. Electronic address: jean-yves.roignant@unil.ch.

Mol Cell ; 84(9): 1631-1632, 2024 May 02.

Article en En | MEDLINE | ID: mdl-38701738

ABSTRACT

ABSTRACT

In this issue of Molecular Cell, Hao et al.1 demonstrate that the RNA helicase DDX21 recruits the m6A methyltransferase complex to R-loops, ensuring proper transcription termination and genome stability.

Asunto(s)

ARN Helicasas DEAD-box; ARN Helicasas DEAD-box/metabolismo; ARN Helicasas DEAD-box/genética; Humanos; Estructuras R-Loop; Metiltransferasas/metabolismo; Metiltransferasas/genética; Inestabilidad Genómica; Adenosina/metabolismo; Adenosina/análogos & derivados; Terminación de la Transcripción Genética

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ARN Helicasas DEAD-box Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Suiza

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