Osteoblastoma of the thumb with a novel PRSS44::ALK fusion and literature review of osteoblastoma of hands and feet bones.
Genes Chromosomes Cancer
; 63(5): e23241, 2024 05.
Article
en En
| MEDLINE
| ID: mdl-38738966
ABSTRACT
Osteoblastomas (OBs) are benign neoplasms constituting approximately 1% of primary bone tumors with a predilection for the spine and sacrum. We describe an OB of the proximal phalanx of the left thumb in a 38-year-old female. MRI of left hand demonstrated a 29-mm mildly expansile enhancing lesion involving the entire proximal phalanx of the first digit. Histology displayed a bone-forming tumor consisting of trabeculae of remodeled woven bone framed by plump osteoblasts in a vascularized background. Next-generation sequencing analysis identified a PRSS44ALK fusion gene.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pulgar
/
Neoplasias Óseas
/
Osteoblastoma
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Genes Chromosomes Cancer
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos