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TrxT and dhd are dispensable for Drosophila brain development but essential for l(3)mbt brain tumour growth.
Molnar, Cristina; Heinen, Jan Peter; Reina, Jose; Llamazares, Salud; Palumbo, Emilio; Pollarolo, Giulia; Gonzalez, Cayetano.
Afiliación
  • Molnar C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Carrer Baldiri Reixac, 10, 08028, Barcelona, Spain.
  • Heinen JP; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Carrer Baldiri Reixac, 10, 08028, Barcelona, Spain.
  • Reina J; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Carrer Baldiri Reixac, 10, 08028, Barcelona, Spain.
  • Llamazares S; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Carrer Baldiri Reixac, 10, 08028, Barcelona, Spain.
  • Palumbo E; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003, Barcelona, Spain.
  • Pollarolo G; Universitat Pompeu Fabra (UPF), 08002, Barcelona, Spain.
  • Gonzalez C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Carrer Baldiri Reixac, 10, 08028, Barcelona, Spain.
EMBO Rep ; 25(7): 2842-2860, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38750349
ABSTRACT
Expression of the Drosophila cancer-germline (CG), X-linked, head-to-head gene pair TrxT and dhd is normally germline-specific but becomes upregulated in brain tumours caused by mutation in l(3)mbt. Here, we show that TrxT and dhd play a major synergistic role in the emergence of l(3)mbt tumour-linked transcriptomic signatures and tumour development, which is remarkable, taking into account that these two genes are never expressed together under normal conditions. We also show that TrxT, but not dhd, is crucial for the growth of l(3)mbt allografts, hence suggesting that the initial stages of tumour development and long-term tumour growth may depend on different molecular pathways. In humans, head-to-head inverted gene pairs are abundant among CG genes that map to the X chromosome. Our results identify a first example of an X-linked, head-to-head CG gene pair in Drosophila, underpinning the potential of such CG genes, dispensable for normal development and homoeostasis of somatic tissue, as targets to curtail malignant growth with minimal impact on overall health.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Encéfalo / Neoplasias Encefálicas / Proteínas de Drosophila Límite: Animals / Humans Idioma: En Revista: EMBO Rep Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Encéfalo / Neoplasias Encefálicas / Proteínas de Drosophila Límite: Animals / Humans Idioma: En Revista: EMBO Rep Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: España