RB1: governor of the cell cycle in health and disease-a primer for the practising pathologist.
J Clin Pathol
; 77(7): 435-438, 2024 Jun 19.
Article
en En
| MEDLINE
| ID: mdl-38772617
ABSTRACT
RB1 stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough in comprehending cancer development. This overview delves into the role of RB1 in both health and disease, exploring its association with the tumourigenesis of various cancers and a distinct subset of soft-tissue neoplasms. Additionally, we discuss the application of immunohistochemistry and fluorescence in situ hybridisation to detect RB1 alterations.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas de Unión a Retinoblastoma
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
J Clin Pathol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Bélgica