2D Materials Kill Bacteria from Within.
Nano Lett
; 24(22): 6506-6512, 2024 Jun 05.
Article
en En
| MEDLINE
| ID: mdl-38789389
ABSTRACT
Early work demonstrated that some two-dimensional (2D) materials could kill bacteria by using their sharp edges to physically rupture the bacteria envelope, which presents distinct advantages over traditional antibiotics, as bacteria are not able to evolve resistance to the former. This mechano-bactericidal mode of action, however, suffers from low antibacterial efficiency, fundamentally because of random orientation of 2D materials outside the bacteria, where the desirable "edge-to-envelope" contacts occur with low probability. Here, we demonstrate a proof-of-concept approach to significantly enhance the potency of the mechano-bactericidal activity of 2D materials. This approach is in marked contrast with previous work, as the 2D materials are designed to be in situ generated inside the bacteria from a molecularly engineered monomer in a self-assembled manner, profoundly promoting the probability of the "edge-to-envelope" contacts. The rationale in this study sheds light on a mechanically new nanostructure-enabled antibacterial strategy to combat antibiotic resistance.
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1
Bases de datos:
MEDLINE
Asunto principal:
Nanoestructuras
/
Antibacterianos
Idioma:
En
Revista:
Nano Lett
Año:
2024
Tipo del documento:
Article