Your browser doesn't support javascript.
loading
Intracranial arterial calcification in patients with unruptured and ruptured intracranial aneurysms.
Kamphuis, Maarten J; van der Kamp, Laura T; Lette, Edwin; Rinkel, Gabriel J E; Vergouwen, Mervyn D I; van der Schaaf, Irene C; de Jong, Pim A; Ruigrok, Ynte M.
Afiliación
  • Kamphuis MJ; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. m.j.kamphuis-5@umcutrecht.nl.
  • van der Kamp LT; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. m.j.kamphuis-5@umcutrecht.nl.
  • Lette E; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Rinkel GJE; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Vergouwen MDI; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • van der Schaaf IC; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • de Jong PA; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Ruigrok YM; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Eur Radiol ; 34(11): 7517-7525, 2024 Nov.
Article en En | MEDLINE | ID: mdl-38806803
ABSTRACT

OBJECTIVES:

Arterial calcification is thought to protect against rupture of intracranial aneurysms, but studies in a representative population of intracranial aneurysm patients have not yet been performed. The aim was to compare the prevalence of aneurysm wall calcification and intracranial carotid artery calcification (ICAC) between patients with an unruptured intracranial aneurysm (UIA) and a ruptured intracranial aneurysm (RIA). MATERIALS AND

METHODS:

We matched 150 consecutive UIA patients to 150 RIA patients on age and sex. Aneurysm wall calcification and ICAC were quantified on non-contrast enhanced computed tomography images with the modified Agatston score. We compared the prevalence of aneurysm wall calcification, ICAC, and severe ICAC (defined as a modified Agatston score in the fourth quartile) between UIA and RIA patients using univariate and multivariate conditional logistic regression models adjusted for aneurysm characteristics and cardiovascular risk factors.

RESULTS:

Aneurysm wall calcification was more prevalent in UIA compared to RIA patients (OR 5.2, 95% CI 2.0-13.8), which persisted after adjustment (OR 5.9, 95% CI 1.7-20.2). ICAC prevalence did not differ between the two groups (crude OR 0.9, 95% CI 0.5-1.8). Severe ICAC was more prevalent in UIA patients (OR 2.0, 95% CI 1.1-3.6), but not after adjustment (OR 1.0, 95% CI 0.5-2.3).

CONCLUSIONS:

Aneurysm wall calcification but not ICAC was more prevalent in UIAs than in RIAs, which corresponds to the hypothesis that calcification may protect against aneurysmal rupture. Aneurysm wall calcification should be further assessed as a predictor of aneurysm stability in prospective cohort studies. CLINICAL RELEVANCE STATEMENT Calcification of the intracranial aneurysm wall was more prevalent in unruptured than ruptured intracranial aneurysms after adjustment for cardiovascular risk factors. Calcification may therefore protect the aneurysm against rupture, and aneurysm wall calcification is a candidate predictor of aneurysm stability. KEY POINTS Aneurysm wall calcification was more prevalent in patients with unruptured than ruptured aneurysms, while internal carotid artery calcification was similar. Aneurysm wall calcification but not internal carotid artery calcification is a candidate predictor of aneurysm stability. Cohort studies are needed to assess the predictive value of aneurysm wall calcification for aneurysm stability.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aneurisma Intracraneal / Aneurisma Roto / Calcificación Vascular Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Radiol Asunto de la revista: RADIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aneurisma Intracraneal / Aneurisma Roto / Calcificación Vascular Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Radiol Asunto de la revista: RADIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos