Phosphine-Catalyzed Stereospecific and Enantioselective Desymmetrizative [3+2] Cycloaddition of MBH Carbonates and N-(2-tert-Butylphenyl)maleimides.
J Org Chem
; 89(12): 9068-9077, 2024 Jun 21.
Article
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| MEDLINE
| ID: mdl-38822804
ABSTRACT
Herein, we report an l-valine-derived amide phosphine-catalyzed [3+2] cyclization of MBH carbonates and N-(2-tert-butylphenyl)maleimides via asymmetric desymmetrization. Bicyclic N-aryl succinimide derivatives bearing three continuous chiral centers with a remote C-N atropisomeric chirality were constructed stereospecifically and enantioselectively. A wide variety of MBH carbonates could be employed in this process to deliver highly optically pure succinimide derivatives in moderate to excellent yields.
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
/
J. org. chem
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Journal of organic chemistry
Año:
2024
Tipo del documento:
Article