Prevalence and clinical profiles of primary sclerosing cholangitis in China: Data from electronic medical records and systematic literature retrieval.
J Autoimmun
; 147: 103264, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38843578
ABSTRACT
BACKGROUND & AIMS:
Epidemiology of primary sclerosing cholangitis (PSC) is lacking in China. We aimed to estimate the period prevalence and depict the clinical features of PSC in China.METHODS:
We identified and included PSC cases between 2000 and 2023 from two sources electronic medical records (EMR) and systematical literature retrieval (SLR). The period prevalence of PSC was estimated by the multiplier method. Rate ratios (RRs) for PSC prevalence in relation to macroeconomic indicators were calculated by the negative binomial regression model.RESULTS:
A total of 1358 PSC cases were retrieved from 299 hospitals (162 from EMR and 1196 from SLR). Males accounted for 55.7 % of the PSC cases and 25.7 % had concomitant inflammatory bowel disease (IBD). The estimated period prevalence of PSC from 2000 to 2023 was 2.36 (95 % CI 1.82, 3.34) per 100,000. Males had a numerically higher PSC prevalence than females (2.56, 95 % CI 1.97, 3.63 vs. 2.14, 95 % CI 1.65, 3.04 per 100,000). The highest prevalence of PSC was in East China at 4.87 (95 % CI 3.44, 7.18) per 100,000, followed by North China at 2.94 (95 % CI 2.33, 3.74) per 100,000, and the lowest in South China at 0.92 (95 % CI 0.66, 1.30) per 100,000. Regional per capita GDP (RR 1.65, 95 % CI 1.03, 2.65) and healthcare expenditure (RR 1.94, 95 % CI 1.13, 3.38) were identified to be associated with PSC prevalence.CONCLUSION:
Our study showed the estimated PSC prevalence varied within China, but was generally lower than that in Western countries.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Colangitis Esclerosante
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Registros Electrónicos de Salud
Límite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Autoimmun
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China