Rapid rituximab administration: Safety of 60-minute infusions in malignant and benign haematological disease.
J Oncol Pharm Pract
; : 10781552241260863, 2024 Jun 07.
Article
en En
| MEDLINE
| ID: mdl-38847136
ABSTRACT
INTRODUCTION:
Rituximab is a chimeric monoclonal antibody used to treat a range of malignant and benign haematological conditions. To minimise the risk of infusion-related toxicity, initial infusions are administered slowly over 4-6â h. In the absence of significant reactions, subsequent doses are often administered over an off-label rate of 90â min. In response to emergent data, our site adopted the use of rapid 60-min infusions for third and subsequent doses. This study aimed to review the safety and ongoing feasibility of 60-min rituximab infusions following institutional practice change.METHODS:
Pharmacy dispensing records were used to identify all rituximab infusions dispensed under the direction of a haematologist between 1 January 2023 and 30 June 2023. Electronic medical records were reviewed retrospectively to characterise the incidence of infusion reactions.RESULTS:
Eight-two patients received a total of 262 rituximab infusions, including 54 patients who received a total of 113 rapid 60-min infusions. No infusion-related reactions were observed with 60-min administration. Five patients who experienced grade 1-2 infusion reactions with their first or second dose of rituximab safely received 60-min infusions for third and subsequent doses without additional premedication. Indications for treatment included non-Hodgkin's lymphoma (76.99%), non-malignant disease states (17.70%), chronic lymphocytic leukaemia (3.54%) and post-transplant lymphoproliferative disorder (1.77%).CONCLUSION:
In the absence of severe reactions to initial and second doses, administration of rituximab over 60â min is well tolerated in patients with malignant and benign haematological disease.
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
J Oncol Pharm Pract
Asunto de la revista:
FARMACIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Australia