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Diurnal variation of cisplatin-induced renal toxicity in ICR mice.
Tominaga, Sarah; Yoshioka, Hiroki; Hasegawa, Tatsuya; Suzui, Masumi; Maeda, Tohru; Miura, Nobuhiko.
Afiliación
  • Tominaga S; Graduate School of Pharmaceutical Sciences, Kinjo Gakuin University, 2-1723 Omori, Moriyamaku, Nagoya, Aichi, 463-8521, Japan; Department of Neurotoxicology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
  • Yoshioka H; Faculty of Pharmacy, Gifu University of Medical Science, 4-3-3 Nijigaoka, Kani, Gifu, 509-0293, Japan; Department of Hygiene, Kitasato University, School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriya
  • Hasegawa T; Department of Environmental Biochemistry, Mount Fuji Research Institute, 5597-1 Kamiyoshidakenmarubi, Fujiyoshida, Yamanashi, 403-0005, Japan.
  • Suzui M; Department of Neurotoxicology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
  • Maeda T; Graduate School of Pharmaceutical Sciences, Kinjo Gakuin University, 2-1723 Omori, Moriyamaku, Nagoya, Aichi, 463-8521, Japan; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyamaku, Nagoya, Aichi, 463-8521, Japan.
  • Miura N; Department of Health Science, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa, 245-2006, Japan. Electronic address: nobuhiko.miura@yok.hamayaku.ac.jp.
Biochem Biophys Res Commun ; 725: 150266, 2024 09 17.
Article en En | MEDLINE | ID: mdl-38878759
ABSTRACT
Cisplatin (CDDP) is a platinum-based anticancer drug widely prescribed for its effectiveness in treating various forms of cancer. However, its major side effect is nephrotoxicity. Although several methods have been developed to mitigate CDDP-induced nephrotoxicity, an optimal approach has yet to be established. This study aimed to investigate the "chronotoxicity" of CDDP as a potential strategy to reduce its side effects. Male ICR mice were treated with CDDP (20 mg/kg, intraperitoneal injection, one shot) at zeitgeber time (ZT) 2 or ZT14 (light or dark phase). After 72 h, we collected plasma and kidney and evaluated several markers. We found that body weight change between ZT2 and ZT14 by CDDP was comparable. In contrast, many toxicological factors, such as plasma blood urine nitrogen, plasma creatinine, renal oxidative stress (malondialdehyde), DNA damage (γH2AX), acute kidney injury biomarker (KIM-1), and inflammation (Tnfα), were significantly induced at ZT14 compared to than that of ZT2. Our present data suggested that chronotoxicology might provide beneficial information on the importance of administration timings for toxic evaluations and unacceptable side effects.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ritmo Circadiano / Cisplatino / Riñón / Ratones Endogámicos ICR / Antineoplásicos Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2024 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ritmo Circadiano / Cisplatino / Riñón / Ratones Endogámicos ICR / Antineoplásicos Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2024 Tipo del documento: Article País de afiliación: Japón