Risk of Adverse Neonatal Events in Pregnancies Complicated by Severe Maternal Morbidity.
J Pediatr
; 273: 114149, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-38880382
ABSTRACT
OBJECTIVE:
To investigate the risk of adverse neonatal events after a pregnancy complicated by severe maternal morbidity. STUDYDESIGN:
We analyzed a population-based cohort of deliveries in Quebec, Canada, between 2006 and 2021. The main exposure measure was severe maternal morbidity, comprising life-threatening conditions such as severe hemorrhage, cardiac complications, and eclampsia. The outcome included adverse neonatal events such as very preterm birth (gestational age <32 weeks), bronchopulmonary dysplasia, hypoxic ischemic encephalopathy, and neonatal death. Using log-binomial regression models, we estimated adjusted relative risks (RRs) and 95% confidence intervals (CIs) for the association between severe maternal morbidity and adverse neonatal events.RESULTS:
Among 1â199â112 deliveries, 29â992 (2.5%) were complicated by severe maternal morbidity and 83â367 (7.0%) had adverse neonatal events. Severe maternal morbidity was associated with 2.96 times the risk of adverse neonatal events compared with no morbidity (95% CI 2.90-3.03). Associations were greatest for mothers who required assisted ventilation (RR 5.86, 95% CI 5.34-6.44), experienced uterine rupture (RR 4.54, 95% CI 3.73-5.51), or had cardiac complications (RR 4.39, 95% CI 3.98-4.84). Severe maternal morbidity was associated with ≥3 times the risk of neonatal death and hypoxic-ischemic encephalopathy and ≥10 times the risk of very preterm birth and bronchopulmonary dysplasia.CONCLUSIONS:
Severe maternal morbidity is associated with an elevated risk of adverse neonatal events. Better prevention of severe maternal morbidity may help reduce burden of severe neonatal morbidity.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Complicaciones del Embarazo
Límite:
Adult
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Female
/
Humans
/
Newborn
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Pregnancy
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Pediatr
Año:
2024
Tipo del documento:
Article