CD63 sorts cholesterol into endosomes for storage and distribution via exosomes.
Nat Cell Biol
; 26(7): 1093-1109, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38886558
ABSTRACT
Extracellular vesicles such as exosomes are now recognized as key players in intercellular communication. Their role is influenced by the specific repertoires of proteins and lipids, which are enriched when they are generated as intraluminal vesicles (ILVs) in multivesicular endosomes. Here we report that a key component of small extracellular vesicles, the tetraspanin CD63, sorts cholesterol to ILVs, generating a pool that can be mobilized by the NPC1/2 complex, and exported via exosomes to recipient cells. In the absence of CD63, cholesterol is retrieved from the endosomes by actin-dependent vesicular transport, placing CD63 and cholesterol at the centre of a balance between inward and outward budding of endomembranes. These results establish CD63 as a lipid-sorting mechanism within endosomes, and show that ILVs and exosomes are alternative providers of cholesterol.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Endosomas
/
Colesterol
/
Exosomas
/
Tetraspanina 30
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Cell Biol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Francia