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Influence of Biomarkers on Mortality among Patients with Hepatic Metastasis of Colorectal Cancer Treated with FOLFOX/CAPOX and FOLFIRI/CAPIRI, Including Anti-EGFR and Anti-VEGF Therapies.
Popovici, Dorel; Stanisav, Cristian; Sima, Laurentiu V; Negru, Alina; Murg, Sergiu Ioan; Carabineanu, Adrian.
Afiliación
  • Popovici D; Department of Oncology, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
  • Stanisav C; Departments of Radiology, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
  • Sima LV; Department of Surgical Semiology, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
  • Negru A; Department of Cardiology, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
  • Murg SI; Doctoral School of Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 1 Decembrie Square 10, 410073 Oradea, Romania.
  • Carabineanu A; Department of Surgical Semiology, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Medicina (Kaunas) ; 60(6)2024 Jun 19.
Article en En | MEDLINE | ID: mdl-38929620
ABSTRACT
Background and

objectives:

Colorectal cancer is a major global health concern, with a significant increase in morbidity and mortality rates associated with metastatic stages. This study investigates the prognostic significance of various clinical and laboratory parameters in patients with metastatic CRC. Materials and

Methods:

A retrospective cohort of 188 CRC patients with hepatic metastasis from the OncoHelp Association in Timisoara was analyzed from January 2016 to March 2023. Data on demographics, clinical characteristics, and biomarkers, such as lymphocyte counts, as well as various inflammation indices, were examined. Statistical analyses included univariate and multivariate logistic regression, Kaplan-Meier survival analysis, and ROC curve assessments.

Results:

Our findings indicate significant associations between survival outcomes and several biomarkers. Higher BMI and lymphocyte counts were linked with better survival rates, while higher values of Neutrophil-Hemoglobin-Lymphocyte (NHL) score, Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR), and Systemic Immune-Inflammation Index (SII) were predictors of poorer outcomes. Notably, the presence of hepatic metastasis at diagnosis was a critical factor, significantly reducing overall survival.

Conclusions:

The study has expanded the current understanding of prognostic factors in CRC, advocating for a multi-dimensional approach to prognostic evaluations. This approach should consider not only the traditional metrics such as tumor stage and histological grading but also incorporate a broader spectrum of biomarkers. Future studies should aim to validate these findings and explore the integration of these biomarkers into routine clinical practice, enhancing the precision of prognostic assessments and ultimately guiding more personalized treatment strategies for CRC patients.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Compuestos Organoplatinos / Neoplasias Colorrectales / Protocolos de Quimioterapia Combinada Antineoplásica / Leucovorina / Fluorouracilo / Neoplasias Hepáticas Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Rumanía

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Compuestos Organoplatinos / Neoplasias Colorrectales / Protocolos de Quimioterapia Combinada Antineoplásica / Leucovorina / Fluorouracilo / Neoplasias Hepáticas Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Rumanía