Programmed death of cardiomyocytes in cardiovascular disease and new therapeutic approaches.
Pharmacol Res
; 206: 107281, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38942341
ABSTRACT
Cardiovascular diseases (CVDs) have a complex pathogenesis and pose a major threat to human health. Cardiomyocytes have a low regenerative capacity, and their death is a key factor in the morbidity and mortality of many CVDs. Cardiomyocyte death can be regulated by specific signaling pathways known as programmed cell death (PCD), including apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis, etc. Abnormalities in PCD can lead to the development of a variety of cardiovascular diseases, and there are also molecular-level interconnections between different PCD pathways under the same cardiovascular disease model. Currently, the link between programmed cell death in cardiomyocytes and cardiovascular disease is not fully understood. This review describes the molecular mechanisms of programmed death and the impact of cardiomyocyte death on cardiovascular disease development. Emphasis is placed on a summary of drugs and potential therapeutic approaches that can be used to treat cardiovascular disease by targeting and blocking programmed cell death in cardiomyocytes.
Palabras clave
Atorvastatin (PubChem CID: 60823); Cardiomyocyte; Cardiovascular diseases; Carvedilol (PubChem CID: 2585); Dapagliflozin (PubChem CID: 9887712); Dexmedetomidine (PubChem CID:6918081); Drug; Fluvastatin (PubChem CID: 23679527); Melatonin (PubChem CID:896); Probucol (PubChem CID: 4912); Programmed cell death; SP600125 (PubChem CID: 8515); Scutellarin (PubChem CID: 185617); Treatment; Trimetazidine (PubChem CID: 83201)
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
/
Miocitos Cardíacos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Pharmacol Res
Asunto de la revista:
FARMACOLOGIA
Año:
2024
Tipo del documento:
Article