Beyond Amyloid-ß: Reevaluating Its Physiological Role to Find Safe Therapies Against Alzheimer's Disease.

ABSTRACT

This commentary critically examines the long-standing emphasis on amyloid-ß (Aß)-based therapies in Alzheimer's disease (AD), despite numerous clinical trial failures. It highlights the urgency to reassess research methodologies and challenges the initiation of anti-Aß trials in preclinical stages of the disease without conclusive proofs of their safety and efficacy. Instead, a comprehensive approach that considers Aß's physiological roles and addresses AD complex nature is suggested, encouraging the idea that clinical trial failures may result from targeting the wrong mechanism. Evidence-based scientific research is needed to advance with AD treatment, moving beyond the current conception of Aß hypothesis.