Alterations of Placental Sodium in Preeclampsia: Trophoblast Responses.
Hypertension
; 81(9): 1924-1934, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38966986
ABSTRACT
BACKGROUND:
Evidence suggests that increasing salt intake in pregnancy lowers blood pressure, protecting against preeclampsia. We hypothesized that sodium (Na+) evokes beneficial placental signals that are disrupted in preeclampsia.METHODS:
Blood and urine were collected from nonpregnant women of reproductive age (n=26) and pregnant women with (n=50) and without (n=55) preeclampsia, along with placental biopsies. Human trophoblast cell lines and primary human trophoblasts were cultured with varying Na+ concentrations.RESULTS:
Women with preeclampsia had reduced placental and urinary Na+ concentrations, yet increased urinary angiotensinogen and reduced active renin, aldosterone concentrations, and osmotic response signal TonEBP (tonicity-responsive enhancer binding protein) expression. In trophoblast cell cultures, TonEBP was consistently increased upon augmented Na+ exposure. Mechanistically, inhibiting Na+/K+-ATPase or adding mannitol evoked the TonEBP response, whereas inhibition of cytoskeletal signaling abolished it.CONCLUSIONS:
Enhanced Na+ availability induced osmotic gradient-dependent cytoskeletal signals in trophoblasts, resulting in proangiogenic responses. As placental salt availability is compromised in preeclampsia, adverse systemic responses are thus conceivable.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Placenta
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Preeclampsia
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Sodio
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Trofoblastos
Límite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Hypertension
Año:
2024
Tipo del documento:
Article